Along with its needed effects, Fioricet may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Medication Overuse Headache
A medication-overuse headache (MOH), once known as a rebound headache, drug-induced headache, or medication-misuse headache, is a chronic headache that develops as a result of prolonged and frequent use of certain medications for acute headaches. Such headaches are a common side effect of a number of classes of medications used to treat headaches.
According to the International Classification of Headache Disorders, MOH is diagnosed when a person has a headache 15 or more times a day and, in the case of combination pain relievers like Fioricet and Fiorinal, has been taking the drug for 10 days a month for more than three months.
In addition, medication overuse headaches are often not responsive to preventive headache medications. This lack of response to other medications is often a clue to doctors that a medication overuse headache has developed.
Medications containing butalbital should be limited to two days per week to avoid this rebound effect
Fioricet Side Effects
Check with your doctor immediately if any of the following side effects occur:
- Bleeding or crusting sores on lips
- chest pain
- fever with or without chills
- hive-like swellings (large) on eyelids, face, lips, and/or tongue
- muscle cramps or pain
- red, thickened, or scaly skin
- shortness of breath, troubled breathing, tightness in chest, or wheezing
- skin rash, itching, or hives
- sores, ulcers, or white spots in mouth (painful)
Symptoms of overdose
- Anxiety, confusion, excitement, irritability, nervousness, restlessness, or trouble in sleeping (severe, especially with products containing caffeine)
- convulsions (seizures) (for products containing caffeine)
- diarrhea, especially if occurring together with increased sweating, loss of appetite, and stomach cramps or pain
- dizziness, lightheadedness, drowsiness, or weakness, (severe)
- frequent urination (for products containing caffeine)
- hallucinations (seeing, hearing, or feeling things that are not there)
- increased sensitivity to touch or pain (for products containing caffeine)
- muscle trembling or twitching (for products containing caffeine)
- nausea or vomiting, sometimes with blood
- ringing or other sounds in ears (for products containing caffeine)
- seeing flashes of “zig-zag” lights (for products containing caffeine)
- shortness of breath or unusually slow or troubled breathing
- slow, fast, or irregular heartbeat
- slurred speech
- swelling, pain, or tenderness in the upper abdomen or stomach area
- unusual movements of the eyes
Check with your doctor as soon as possible if any of the following side effects occur:
- Confusion (mild)
- mental depression
- unusual excitement (mild)
- Bloody or black, tarry stools
- bloody urine
- pinpoint red spots on skin
- swollen or painful glands
- unusual bleeding or bruising
- unusual tiredness or weakness (mild
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bloated or “gassy” feeling
- dizziness or lightheadedness (mild)
- drowsiness (mild)
- nausea, vomiting, or stomach pain (occurring without other symptoms of overdose)
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Butalbital exerts its toxicity through excessive sedation, resulting in respiratory depression and ultimately death via hypoxia.
Nonlethal overdoses may also result in coma and death. There is no specific antidote to barbiturate overdose; treatment is supportive, generally including the administration of intravenous saline, naloxone, thiamine, glucose, sodium bicarbonate to alkalize the urine and increase rate of excretion, and activated charcoal via nasogastric tube.
Acetaminophen exerts its toxicity through the production of a toxic metabolite that can cause liver damage at doses as low as four grams.
Larger doses can precipitate acute liver failure, acute kidney injury, or gastrointestinal bleeding; death has been known to occur with ingestion of ten to fifteen grams.
The specific antidote to acetaminophen overdose is N-acetylcysteine